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ea0011p330 | Diabetes, metabolism and cardiovascular | ECE2006

How does glucose insulin potassium improve haemodynamic performance? Evidence for beta-adrenoreceptor and sarcoplasmic reticulum calcium ATPase up-regulation

Ranasinghe AM , Quinn DW , McCabe CJ , Pagano D , Franklyn JA , Bonser RS

Objectives: Glucose insulin potassium (GIK) improves haemodynamic performance following coronary artery bypass graft surgery (CABG). We postulated that this might be secondary to beta-1 adrenergic receptor (ADRB1) up-regulation and changes in myocyte calcium handling.Methods: We performed a randomised double-blind placebo-controlled trial on patients undergoing first time elective/urgent on-pump CABG (LREC approval obtained). A cohort of 48 patients rand...

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ea0011oc59 | ThyroidOC57 British Thyroid Association Award | ECE2006

Tri-iodothyronine improves haemodynamic performance and is associated with improved myocardial protection post on-pump coronary artery bypass grafting

Ranasinghe AM , Quinn DW , Graham TR , Keogh BE , Mascaro CJ , Rooney SJ , Wilson IC , Pagano D , Franklyn JA , Bonser RS

Objectives: Tri-iodothyronine (T3) can improve cardiovascular performance following cardiac surgery. Its effects on myocardial protection are unknown.Methods: We performed two consecutive randomised double-blind placebo-controlled trials (identical management protocols) on patients undergoing first time isolated elective or urgent on-pump coronary artery bypass graft surgery (CABG). Between January 2000 and September 2004, 440 patients were re...

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Endocrine Abstracts

How does glucose insulin potassium improve haemodynamic performance? Evidence for beta-adrenoreceptor and sarcoplasmic reticulum calcium ATPase up-regulation

Tri-iodothyronine improves haemodynamic performance and is associated with improved myocardial protection post on-pump coronary artery bypass grafting

BiosciAbstracts